I just finished re-reading GOTHAM BY GASLIGHT by Mignola.

And the Elseworlds story JLA: ISLAND OF DR MOREAU by Roy Thomas and Steve Pugh

Both great stories, as are many others in comics form that deal with Jack the Ripper.

It's one of those historic mysteries like the Hindenburg explosion, or Hitler's death (or escape), or Amelia Earhardt's disappearance, or similar events, that lend themselves well to expansion in a well-told story (or sometimes not).

Jack the ripper often seems to draw in science-fiction elements and/or conspiracies.
So... maybe some of you know a few good ones I haven't seen. Feel free to list the best (or worst).