Changes in Hormones Menstruation and pregnancy tend to be the most common reasons for breast pain, and it is often a change in cycles that leads to soreness, tenderness or pain. Menopause is characterized by a fluctuation of hormones, and it is the lack of estrogen which results from this which leads to breast pain. Stress levels are also linked to your hormones and fluctuations in hormone levels may be more severe if you are suffering from high levels of stress during menopause.
