Well yeah, his personality's the same. But the characters surrounding him are fairly different.
My biggest problem with Scrubs is that they all act plucky and clever as if they're all aware of the forth wall and just play to it like it's a skit comedy as opposed to what it's supposed to be: a mock drama. I simply cannot take that week after week.
I like the fact that House is in his own world and everyone just tags along for the ride. I admit that the character can get monotonous at times, but I think he's applied more creatively to each scenario since he stands out among the cast.
In the case of Scrubs, it's like they're trying to apply their own personalities to themselves since they're all quippy.
