That trailer pretty much confirms one of my theories:

Warning, Spoiler:
"Madame Kovarian"/Eye-Patch Lady is, in fact, a previous incarnation of Melody Pond/River Song. I bet Eye-Patch lady lost her eye in "battle" with The Doctor in the past (as she was raised to be a weapon against him). Then, she loses her life in a later battle with him, and regenerates into Alex Kingston. Probably loses the patch, now that the regeneration has healed her eye. And The Doctor probably sacrifices himself on the Utah beach to her (in the astronaut suit) in order to fulfill some agreement or something with The Silence. This act of perceived self-sacrifice is what convinces (?) River to become good and turn herself in to Stormgate prison.


At least....that's my current working theory based on what we've seen so far. I'm sure Moffat will come along and acid-trip all over my ideas like I got them off a Saturday morning cartoon...