US 52 is one of five U.S. highways to cross the Mississippi River more than once. It crosses the river three times: at Minneapolis via the Dartmouth Bridge, at St. Paul by the Lafayette Bridge, and between Iowa and Illinois by the Savanna–Sabula Bridge. The others are U.S. Route 61, which crosses the Mississippi four times, U.S. Route 169, which crosses three times, and U.S. Route 2 and U.S. Route 67, which each cross twice.