Well, I know I for one am using one main character in a heroic role (soon): Pete 'the Chimp' Glover (and Kristofer Schanz, who's dead, but... well...) Doc Quantos and TTT are merely supporting cast now, only to appear occasionally, and never in the heroic roles they would've been in during the old days.
TTT is a god-like figure now who is thousands of years old and very wise, and a bit more personable than he was before.
Dr. Henry Quantos is a scientist and medical doctor first and foremost, rather than the hero he was "pre-Crisis" (damn, that phrase slips so easily from these typing fingers) and merely serves a supporting role, the same way I've been using Bibbo since Bibbo the poster has been away...