well, if "unbreakable" was a year one type tale, part 2 could be more of an "establishment" movie, where bruce willis goes out to search for more specific crimes, perhaps stumbling on "the big one." meanwhile, he'd have to now deal with the family live he's regained, keeping a secret identity.
perhaps storylines about his child emulating him, becoming a side-kick, or gaining some of bruce's "powers" with age...
there's definitly a lot of room to continue the story. personally, im happy where it left off. however, i'd definitly see the second chapter.