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Rutgers researchers optimistic about trio of AIDS drugs
The Associated PressResearchers at Rutgers University have developed a trio of drugs they believe can destroy HIV, the virus that causes AIDS, according to a published report.
The drugs, called DAPYs, mimic the virus by changing shape, which enables them to interfere with the way HIV attacks the immune system.
Tests conducted in conjunction with Johnson and Johnson have shown the drug to be easily absorbed with minimal side effects. It also can be taken in one pill, in contrast to the drug cocktails currently taken by many AIDS patients.
"This could be it," Stephen Smith, the head of the department of infectious diseases at Saint Michael's Medical Center in Newark, told The Sunday Star-Ledger of Newark. "We're all looking for the next class of drugs."
A research team led by Rutgers chemist Eddy Arnold pre-published details of the most promising of the three drugs, known as R278474, last month in the electronic edition of the Journal of Medicinal Chemistry. Full details will be published in the journal in early 2005.
Arnold, 47, has worked at dismantling the AIDS virus over the last 20 years. He uses X-ray crystallography, a technique to determine the structure of molecules, the smallest particles that can retain all the characteristics of an element or compound.
The research has targeted reverse transcriptase, a submiscroscopic protein composed of two coiled chains of amino acids. It is considered HIV's key protein.
"Reverse transcriptase is very important in the biology of AIDS," Smith said. "If you can really inhibit reverse transcriptase, you can stop AIDS."
The optimism about R278474 stems from its potential to interfere with an enzyme that the virus needs to copy and insert itself into a human cell.
"We're onto something very, very special," Arnold told the newspaper.
Arnold established his lab at Rutgers' Center for Advanced Biotechnology and Medicine in 1987. His current 30-member research team is partnered with Johnson and Johnson subsidiaries Janssen Pharmaceutica and Tibotec-Virco NV.
An important advancement in Arnold's research came in 1990 when Belgian scientist Paul Janssen was added to the collaboration. Janssen, considered a drug pioneer, published a paper that year that described a new drug that blocked reverse transcriptase but caused resistant strains of the virus to pop up too quickly.
Janssen sought out Arnold, who used crystallography to detail the structure of RT. Their work ultimately led to the RT inhibitors.
Two earlier relatives of R278474, called TMC-120 and TMC-125, have showed promise in clinical trials. Johnson and Johnson officials told the newspaper that the two drugs are of major interest to them, but did not discuss R278474.
"We may eventually win the war against HIV/AIDS. That would be an extremely rewarding and satisfying outcome," Arnold said. "But even to have contributed to helping the health and well-being of the many people infected with HIV will be very satisfying if that were to happen."
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so... this article discusses the potential end to, perhaps, the most involving and "popular" illness that has plagued mankind since the plague ... and you poo poo the thought?
contribute and elaborate, sweetie.
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It's Pariah. Don't look for a coherent or logical thought process.
whomod said: I generally don't like it when people decide to play by the rules against people who don't play by the rules. It tends to put you immediately at a disadvantage and IMO is a sign of true weakness. This is true both in politics and on the internet." Our Friendly Neighborhood Ray-man said: "no, the doctor's right. besides, he has seniority."
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Feh! They need to cure cold sores! Every couple of months I get these painful sores in my mouth, had 'em since I was a kid, and they make life awful!
Knutreturns said: Spoken like the true Greatest RDCW Champ!
All hail King Snarf!
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If I might be a bit more verbose than Pariah, while still echoing his basic point:
I hope Pariah is wrong. However, from what I have read, the HIV virus is extraordinarily adaptive and fast evolving. As such, there is a strong possibility that no "trio of drugs" will remain effective against the virus for very long. In fact, I seem to recall reading that similar trials met early success only to see the drugs become ineffective as the virus changed.
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Quote:
King Snarf said:
Feh! They need to cure cold sores! Every couple of months I get these painful sores in my mouth, had 'em since I was a kid, and they make life awful!
Cold sores aren't a political disease, therefore, not important.
November 6th, 2012: Americas new Independence Day.
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Quote:
rex said:
Cold sores aren't a political disease, therefore, not important.
AIDS is fare more than a political disease. Just ask anyone in sub-Saharan Africa.
We all wear a green carnation.
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I don't care about Africa.
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I am incredibly surprised. Incredibly.
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Sadly, I agree with Pariah and the G-man.
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As with any drug (including the much overused and abused antibiotic drugs) it will become useless once the viruses adapt. That's no reason to not keep trying and hoping though.
We're all gonna die one day from the mutated superflu virus anyways.
But regardless, i sense a dismissive tone here. As if AIDS, in it's own way is a GOOD thing. Which I find rather disturbing.
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No dismissive tone from me.
Who, in fact, do you see such a tone from?
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Quote:
whomod said:
We're all gonna die one day from the mutated superflu virus anyways.
You still believe that BS?
November 6th, 2012: Americas new Independence Day.
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Quote:
rex said:
Quote:
whomod said:
We're all gonna die one day from the mutated superflu virus anyways.
You still believe that BS?
Well, considering I had the flu this year FOR 3 CONSECUTIVE WEEKS, yeah, i do.
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Quote:
Rob Kamphausen said:
so... this article discusses the potential end to, perhaps, the most involving and "popular" illness that has plagued mankind since the plague ... and you poo poo the thought?
contribute and elaborate, sweetie.
AIDS/HIV, like any diseases, are evolving ones. Even if we cure those, a splinter resembling them will just show up again. And the slightest change in cellular body could mean the epitome of hoplessness on a scientists part. And on that note, I don't think we're going to ever cure the full effect of aids.
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It would help if the gays stopped spreading it.
November 6th, 2012: Americas new Independence Day.
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Wow this is great news if it works. This could be a new lease on life for so many people.
Fair play!
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If it works for one person it's worth it. Here's hopin'!!
Old men, fear me! You will shatter under my ruthless apathetic assault!
Uschi - 2
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"I am convinced that this world is of no importance, and that the only people who care about dates are imbeciles and Spanish teachers." -- Jean Arp, 1921
"If Jesus came back and saw what people are doing in his name, he would never never stop throwing up." - Max von Sydow, "Hannah and Her Sisters"
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Quote:
Rob Kamphausen said:
Rutgers researchers optimistic about trio of AIDS drugs
The Associated Press
Researchers at Rutgers University have developed a trio of drugs they believe can destroy HIV, the virus that causes AIDS, according to a published report.
Quote:
Pariah said:
Nope. Not gonna happen.
Quote:
the G-man said:
I hope Pariah is wrong. However, from what I have read, the HIV virus is extraordinarily adaptive and fast evolving. As such, there is a strong possibility that no "trio of drugs" will remain effective against the virus for very long. In fact, I seem to recall reading that similar trials met early success only to see the drugs become ineffective as the virus changed.
Case in point, from today's New York Times:
New York's first diagnosed case of highly drug-resistant HIV in a person never before treated for the virus is ``a wake up call'' to anyone who has unprotected sex, the city's health commissioner said Friday.
The patient, a man in his mid-40s who had unprotected sex with other men, contracted a strain of HIV that is ``difficult or impossible to treat and which appears to progress rapidly to AIDS,'' said the Health Commissioner Dr. Thomas Frieden.
The commissioner said the city's health authorities are working with the federal Centers for Disease Control in Atlanta to find other possible cases of the drug-resistant HIV strain that quickly turns into AIDS.
The patient's three-class antiretroviral-resistant HIV did not respond to three of four classes of anti-retroviral medication most commonly prescribed. He is now receiving a fourth ``cocktail'' in hopes his rare HIV strain will respond, health officials said.
Drug resistance is increasingly common among HIV-positive people, including some who had never been treated before -- but not with such a fast progression to AIDS, Valdiserri said.
What makes this case important to scientists is ``the double whammy of resistance to three classes of drugs, in combination with the rapid clinical course of the HIV to AIDS,'' Valdiserri said. ``The message to the American public is that HIV remains a very formidable adversary. We can't let down our vigilance.''
Dr. James Braun, president of the Physicians Research Network, a New York-based not-for-profit organization of clinicians serving HIV patients, said the New York case comes as no surprise: ``We believe that the transmission of treatment-resistant HIV was a disaster waiting to happen, particularly in communities where safer sex is not practiced regularly
One of those times where it really, really, sucks to be right.
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Hey, if people would stop fornicating and sodomizing, there'd be no problem.
As it stands though, the adaptive nature of the virus ensures people better check themselves before deciding to behave immorally.
(edit: Check themselves as in morally, not medically)
[url=http://www.robkamphausen.com/ubbthreads/...e=0&fpart=2 ]the G-man said[/url]
Wednesday and I have an open relationship. And we believe in sharing.
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Quote:
whomod said:
It sounds as if as long as only black people and gays get it, it's at a good comfort level for some.
Incredible!
A disease is a disease. It doesn't pick and choose it's victims. That being the case, is it anyones fault that the ones getting it the most are gays and blacks?
A little self-control goes a long way. If one is unable to do that, then sayonara, baby.
Typical liberal excuse-maker. 
[url=http://www.robkamphausen.com/ubbthreads/...e=0&fpart=2 ]the G-man said[/url]
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Quote:
rex said:
It would help if the gays stopped spreading it.
tsk...  Such self-loathing...
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I think Jeff Gannon is actually whomod. Seriously.
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More bad news here: The threat that an entirely new AIDS epidemic might ravage the country sent shock waves through the medical community yesterday.
The discovery of a virulent new strain of HIV that is resistant to three of the four types of drugs used to fight the virus means that all the recent advances in treatment may go from cutting edge to obsolete overnight, experts feared.
"This is just scary. This just throws out the medicine chest," said Dr. Charles Gonzalez, an AIDS specialist at NYU Medical Center and Bellevue Hospital.
"In the beginning of the AIDS crisis, we had no treatment. Again, we have absolutely no treatment," said Gonzalez, a member of a network that monitors new AIDS cases in New York. "Everything we're using now to treat this guy is jury-rigged."
Drug-resistant HIV isn't new. But what makes this new bug unique is that it is resistant to 19 of the 20 drugs now on the market.
"This may be the tip of the iceberg. It's going to get ugly," Gonzalez said. "If this one starts getting around, we're back to the early '80s."
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Here's the good news.
HIV/AIDS is preventable.
You can get free condoms, you can smoke heroine.
Let's get with the program.
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Quote:
Jim Jackson said:
Quote:
rex said:
Cold sores aren't a political disease, therefore, not important.
AIDS is fare more than a political disease. Just ask anyone in sub-Saharan Africa.
sud-saharan Africa, a Mister Charles Darwin to see you.
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Quote:
Ultimate Jaburg53 said:
You can get free condoms,
But if you do that the theory that Uncle God sent it to punish the sodomists and the sinful negros is gonna go to hell!!! No, we must prevent people from saving themselves from AIDS by saying something stupid, like, I don't know, it's morally wrong to put rubber in your cock, or something...
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Quote:
I'm Not Mister Mxypltk said:
But if you do that the theory that Uncle God sent it to punish the sodomists and the sinful negros is gonna go to hell!!!
Not to mention the equally stupid theory that the CIA created it in a lab to kill black people and gays.
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Quote:
the G-man said:
Quote:
I'm Not Mister Mxypltk said:
But if you do that the theory that Uncle God sent it to punish the sodomists and the sinful negros is gonna go to hell!!!
Not to mention the equally stupid theory that the CIA created it in a lab to kill black people and gays.
http://carpenoctem.tv/cons/aids.html
The CIA has a now on-the-record history of testing various agents of biological weapons on civilian populations.
Bow ties are coool.
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We already are 15000+ posts
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Quote:
the G-man said:
Quote:
I'm Not Mister Mxypltk said:
But if you do that the theory that Uncle God sent it to punish the sodomists and the sinful negros is gonna go to hell!!!
Not to mention the equally stupid theory that the CIA created it in a lab to kill black people and gays.
you mean they didn't 
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Quote:
I'm Not Mister Mxypltk said:
Quote:
Ultimate Jaburg53 said:
You can get free condoms,
But if you do that the theory that Uncle God sent it to punish the sodomists and the sinful negros is gonna go to hell!!! No, we must prevent people from saving themselves from AIDS by saying something stupid, like, I don't know, it's morally wrong to put rubber in your cock, or something...
Yea, was Mother Teresa just looking for job security or what?
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Oh, and...
Every sperm is sacred
Every sperm is great
and if a sperm is wasted
God gets quite irate.
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Quote:
the G-man said:
Quote:
I'm Not Mister Mxypltk said:
But if you do that the theory that Uncle God sent it to punish the sodomists and the sinful negros is gonna go to hell!!!
Not to mention the equally stupid theory that the CIA created it in a lab to kill black people and gays.
Actually that one gets props for being funny and not creepy like the other one.
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And now for something completely diffrent... The Banana fish. 
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That wacky CIA, always causing trouble.
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i think the CIA created Pimp My Ride to kill white people....
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