I've taken breaks from certain titles, but I doubt the day will ever come where I'll drop comics for good.
I have a selective casualness where comics are concerned, that allows me to enjoy certain stories for what they are, as long as they're well written - even if they undo other good stories. And there are quite a few titles that are able to hold my interest as a result. I sometimes get the feeling that fans feel obligated to hate or like certain writers that I don't feel. As long as I like the story, and it works, I won't complain.
There are some changes, however, that I cannot stand (Jason Todd should still be dead, and I don't like what I'm overhearing about Lieberman's treatment of Batman's Rogues.) I also don't like overly convoluted backgrounds that make a title impossible to follow, or ressurections for the sake of resurrections.