I don't vouch for its accuracy, but the big rumor is that "One More Day" will result in a Spiderman "reboot." They won't kill MJ, the rumor goes, only deage her and Peter to high school or college and split them up.
If you think about it, it's not that surprising that Marvel would be looking at rebooting some, or all, of its' characters. DC "had" to do it twenty years ago and they started publishing approximately twenty years before the Marvel age of comics.
